To successfully carry out the goal of the EFI, expertise is required from diverse disciplines to develop, optimize, and guide the integrated sequence/structure‑based strategy for predicting and verifying enzymatic functions. The EFI is formed by 13 principal investigators and also interacts regularly with an external advisory committee members and NIGMS officials.
EFI Principal Investigators
John A. Gerlt, University of Illinois, Urbana-Champaign, PD/PI of the EFI and, also, Director of the EN Bridging Project, is a mechanistic enzymologist and an expert in the EN superfamily.
Karen N. Allen, Boston University, CoDirector of the HAD Bridging Project, is both a mechanistic enzymologist and a structural biologist and an expert in the HAD superfamily.
Steven C. Almo, Albert Einstein College of Medicine, Director of the Protein and Structure Cores, is a structural biologist.
Squire Booker, Pennsylvania State University, Director of the Radical SAM Pilot Project, is an enzymologist with expertise pertaining to the Radical SAM and Glycyl Radical Enzyme superfamilies.
John E. Cronan, University of Illinois, Urbana-Champaign, Director of the Microbiology Core, is a microbial biochemist and an expert in microbial genetics.
Matthew P. Jacobson, University of California, San Francisco, Director of the Computation Core, is an expert in homology modeling and physics‑based molecular docking.
Wladek Minor, University of Virginia, Data and Dissemination Core, is an expert in structural biology and computer science.
Katherine Pollard, Gladstone Institutes, Director of the SFAM Pilot Project, is an expert in statistical and computational methods for the comparative analysis of large genomic datasets.
C. Dale Poulter, University of Utah, Director of the IS Bridging Project, is an organic chemist, mechanistic enzymologist, and an expert in the isoprenoid synthase superfamily.
Andrej Sali, University of California, San Francisco, Computation Core, is an expert in comparative modeling of protein structures, including their conformationally mobile loops in ligand binding sites.
Brian K. Shoichet, University of California, San Francisco, Computation Core, is an expert in high-throughput docking of ligands in active sites, with the major focus on the identification of novel inhibitors.
Jonathan V. Sweedler, University of Illinois, Urbana-Champaign, Microbiology Core, is an expert in the application of mass spectroscopic methods to solve metabolomic problems.
External Advisory Committee
An Advisory Committee meets with the EFI on annual basis to provide scientific and administrative advice on progress, milestones, and future directions.
Professor Adam Arkin
Department of Bioengineering
University of California, Berkeley
Professor Stephen Burley
Department of Chemistry and Chemical Biology
Professor Benjamin Cravatt
Department of Chemical Physiology
The Scripps Research Institute
Professor Eaton Lattman
Hauptman-Woodward Medical Research Institute
University at Buffalo
Professor Rowena Matthews
Department of Biological Chemistry
University of Michigan
Peter Preusch, Ph.D
Chief of the Biophysics Branch in the Division of Cell Biology and Biophysics
NIGMS Scientific Officier for the EFI
Miles Fabian, Ph.D
Program Director in the Division of Pharmacology, Physiology, and Biological Chemistry
NIGMS Program Director for the EFI