ASBMB 2013 WORKSHOP
Computational Tools for Assigning Enzymatic Functions Workshop:
Examples from the Glutathione Transferase Superfamily
Sunday April 21 @ ASBMB Boston 2013
This EFI workshop featured presentations describing the development and application of high throughput computational “tools” to facilitate functional assignment of unknown enzymes discovered in genome sequencing projects. The glutathione transferase superfamily was used to demonstrate:
1) The use of sequence similarity networks (SSNs) to visualize relationships among members of functionally diverse enzyme superfamilies, identify unknowns, and aid the identification of their functions.
2) The use of Cytoscape to visualize SSNs that are available in the Structure Function Linkage Database (SFLD
3) The use of homology modeling and docking tools to predict substrate specificities.