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The X-ray crystallographic structure and specificity profile of HAD superfamily phosphohydrolase BT1666: comparison of paralogous functions in B. thetaiotaomicron

Lu Z, Dunaway-Mariano D, Allen, KN. (2011) Proteins 79, 3099–3107. PMCID: PMC3356575

The HAD superfamily contains many members that are promiscuous “house-keeping” enzymes.  Having no single substrate (i.e. multi-functional) complicates functional analysis and is an example of a caveat that the EFI must address to develop a robust sequence-based strategy.  This paper from the EFI HAD Bridging Project examines the structure-function relationship between two such promiscuous enzymes, BT1666 and BT4131 from B. thetaiotaomicron, to order to understand the principles that govern differing specificity in similar enzymes.   

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