The Bridging Projects provide the enzymological experience and knowledge that is essential for developing a general strategy for functional assignment.
The Bridging Projects currently focus on four functionally diverse superfamilies (EN, GST, HAD, and IS; AH was phased out in 2012) that span four of the six reaction classes defined by the Enzyme Nomenclature Classification System (E.C.) and four fold classes. The superfamilies range in size from ~10,000 - 80,000 members and differ in domain organization and architecture, catalytic strategies, and metal requirements. Together they represent a broad sampling of the enzyme universe and provide an appropriate set to test the general utility of the integrated strategy under development.